Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells.

@article{Standiford1991AlveolarMC,
  title={Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells.},
  author={Theodore J Standiford and Steven L. Kunkel and Sem H. Phan and Barrett J. Rollins and Robert M. Strieter},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 15},
  pages={9912-8}
}
Many acute and chronic lung diseases are characterized by the presence of increased numbers of activated macrophages. These macrophages are derived predominantly from newly recruited peripheral blood monocytes and may play a role in the amplification and perpetuation of an initial lung insult. The process of inflammatory cell recruitment is poorly understood, although the expression of inflammatory cell-specific chemoattractants and subsequent generation of chemotactic gradients is likely… CONTINUE READING
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