Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.

@article{WienerKronish1993AlveolarEI,
  title={Alveolar epithelial injury and pleural empyema in acute P. aeruginosa pneumonia in anesthetized rabbits.},
  author={Jeanine P. Wiener-Kronish and Tsutomu Sakuma and I Kudoh and J F Pittet and Dale Frank and Leland Dobbs and Michael L. Vasil and Michael A. Matthay},
  journal={Journal of applied physiology},
  year={1993},
  volume={75 4},
  pages={1661-9}
}
We developed an experimental model of acute Pseudomonas aeruginosa pneumonia in anesthetized ventilated rabbits to determine whether bacterial-induced injury to the alveolar epithelium would occur and the effect of the injury on the pleural space. Dose-response studies established that 10(9) colony-forming units of P. aeruginosa (wild-type strain, PAO-1) were required to injure the epithelial barrier and to cause pleural empyema with exudative pleural effusions that contained both the instilled… CONTINUE READING

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