Alveolar epithelial cells regulate the induction of endothelial cell apoptosis.

@article{Wendt1994AlveolarEC,
  title={Alveolar epithelial cells regulate the induction of endothelial cell apoptosis.},
  author={Chris H Wendt and Vitaly A. Polunovsky and Mark S. Peterson and Peter B Bitterman and David H. Ingbar},
  journal={The American journal of physiology},
  year={1994},
  volume={267 4 Pt 1},
  pages={C893-900}
}
Mesenchymal cell apoptosis is important during development, tissue homeostasis, and repair. We sought to determine whether type II alveolar epithelial cells influence mesenchymal cell apoptosis, using the model of tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis of endothelial cells. Apoptosis was quantified by morphology and confirmed by electrophoretic DNA size analysis. Endothelial cells exposed to 20 ng/ml of TNF-alpha for 16 h exhibited apoptosis in 14.4 +/- 1.4% (SE) of the cells… CONTINUE READING

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