Alveolar endotoxin increases alveolar liquid clearance in rats.

  title={Alveolar endotoxin increases alveolar liquid clearance in rats.},
  author={Chrystelle Garat and Sa{\"i}da Rezaiguia and Michel Meignan and Marie Pia D'ortho and A. Harf and Michael A. Matthay and Christian Jayr},
  journal={Journal of applied physiology},
  volume={79 6},
Under some pathological conditions, ion transport across alveolar epithelial cells is downregulated, whereas under other pathological conditions, it may be upregulated. Because endotoxin is a biologically relevant pathological stimulus, we investigated the effect of endotoxin on alveolar epithelial liquid clearance in vivo. Escherichia coli endotoxin (220 micrograms/kg) was instilled into the lungs via the trachea of rats. Then, 24 or 40 h after endotoxin instillation, alveolar and lung liquid… CONTINUE READING
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