Alveolar-capillary membrane dysfunction in chronic heart failure: pathophysiology and therapeutic implications.

@article{Guazzi2000AlveolarcapillaryMD,
  title={Alveolar-capillary membrane dysfunction in chronic heart failure: pathophysiology and therapeutic implications.},
  author={Marco Guazzi},
  journal={Clinical science},
  year={2000},
  volume={98 6},
  pages={633-41}
}
Chronic heart failure (CHF) disturbs the alveolar-capillary interface and increases the resistance to gas transfer. Alveolar-capillary membrane conductance (D(M)) and capillary blood volume (V(c)) are subcomponents of the lung diffusion capacity. Elevation of the capillary pressure causes alveolar-capillary membrane stress failure (i.e. increase in capillary permeability to water and ions, and disruption of local regulatory mechanisms for gas exchange), leading to a decrease in D(M), an… CONTINUE READING

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