Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns

@inproceedings{Langel2014AlveolarMI,
  title={Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns},
  author={Felicia D. Langel and Chih-yuan Chiang and Douglas A Lane and Tara Kenny and Jenifer F. Ojeda and Yang Zhong and Jianwei Che and Yingyao Zhou and Wilson J. Ribot and Krishna P. Kota and Sina Bavari and Rekha Panchal},
  booktitle={PloS one},
  year={2014}
}
Alveolar macrophages (AMs) phagocytose Bacillus anthracis following inhalation and induce the production of pro-inflammatory cytokines and chemokines to mediate the activation of innate immunity. Ames, the virulent strain of B. anthracis, contains two plasmids that encode the antiphagocytic poly-γ-d-glutamic acid capsule and the lethal toxin. The attenuated Sterne strain of B. anthracis, which lacks the plasmid encoding capsule, is widely adapted as a vaccine strain. Although differences in the… CONTINUE READING