Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.

  title={Aluminum promotes the aggregation of Alzheimer's amyloid beta-protein in vitro.},
  author={Masahiro Kawahara and Kenichiro Muramoto and Kazuto Kobayashi and Hiroshi Mori and Yukiko Kuroda},
  journal={Biochemical and biophysical research communications},
  volume={198 2},
Amyloid beta-protein is the major component of senile plaques in the brains of Alzheimer's disease and has an intrinsic tendency to form insoluble aggregates. The aggregation of amyloid beta-protein has been suggested to enhance its neurotoxicity and to play a key role in the amyloid deposition. Here we show, using gel-electrophoresis and immunoblotting, that the aggregation of synthetic amyloid beta-protein (beta 1-40) is promoted by aluminum, a suspected risk factor in Alzheimer's disease… CONTINUE READING
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