Aluminum interaction with phosphoinositide-associated signal transduction

  title={Aluminum interaction with phosphoinositide-associated signal transduction},
  author={Alfred Haug and Biao Shi and V A Vitorello},
  journal={Archives of Toxicology},
Concerning molecular and cellular mechanisms of aluminum toxicity, recent studies support the hypothesis that interactions of aluminum ions with elements of signal transduction pathways are apparently primary events in cells. In the case of the phosphoinositide-associated signalling pathway of neuroblastoma cells, guanine nucleotide-binding proteins (G proteins) and a phosphatidylinositol-4,5-diphosphate (PIP2)-specific phospholipase C are probable interaction sites for inhibitory actions of… CONTINUE READING