Aluminum hydroxide influences not only the extent but also the fine specificity and functional activity of antibody responses to tick-borne encephalitis virus in mice.

@article{Zlatkovic2013AluminumHI,
  title={Aluminum hydroxide influences not only the extent but also the fine specificity and functional activity of antibody responses to tick-borne encephalitis virus in mice.},
  author={Juergen Zlatkovic and Georgios Tsouchnikas and Johanna Jarmer and Christian Koessl and Karin Stiasny and Franz X Heinz},
  journal={Journal of virology},
  year={2013},
  volume={87 22},
  pages={12187-95}
}
Aluminum hydroxide is the most widely used adjuvant in human vaccines and serves as a potent enhancer of antibody production. Its stimulatory effect strongly depends on the adsorption of the antigen to the adjuvant, which may influence antigen presentation and, as a consequence, the fine specificity of antibody responses. Such variations can have functional consequences and can modulate the effectiveness of humoral immunity. Therefore, we investigated the influence of aluminum hydroxide on the… CONTINUE READING
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Vaccines, 6th ed

  • SA Plotkin, WA Orenstein, PA. Offit
  • 2013
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