Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat.

@article{Xu2017AluminumCC,
  title={Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat.},
  author={Feibo Xu and Geert De Jaeger and Hansong Zhao and Kaiyuan Yu and Miao Song and Yanzhu Zhu and Yanfei Li},
  journal={Journal of inorganic biochemistry},
  year={2017},
  volume={174},
  pages={
          55-62
        }
}
Aluminum (Al) is known to exert hepatotoxicity. However, the mechanisms mostly are unclear. Liver is a metabolism organ that maintains the energy level and structural stability of body, mitochondria are the main sites of energy metabolism, thus, we hypothesized that mitochondrial energy metabolism disorder contributes to liver dysfunction in aluminum chloride (AlCl3) treatment rat. To verify the hypothesis, forty male Wistar rats were randomly allocated and orally exposed to 0, 64mg/kg, 128mg… CONTINUE READING

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