Aluminum affects phosphoinositide hydrolysis by phosphoinositidase C.

Abstract

A single phosphoinositidase C (PIC) activity has been purified 500-fold from bovine heart cytosol to a specific activity of 3 mumol phosphatidylinositol (Ptdlns) hydrolyzed/(min.mg protein). The enzyme required Ca2+ for the hydrolysis of polyphosphoinositides or Ptdlns; PIC activity was saturable at micromolar free Ca2+ concentrations with an apparent KCa… (More)

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