Aluminum affects phosphoinositide hydrolysis by phosphoinositidase C.


A single phosphoinositidase C (PIC) activity has been purified 500-fold from bovine heart cytosol to a specific activity of 3 mumol phosphatidylinositol (Ptdlns) hydrolyzed/( protein). The enzyme required Ca2+ for the hydrolysis of polyphosphoinositides or Ptdlns; PIC activity was saturable at micromolar free Ca2+ concentrations with an apparent KCa… (More)


  • Presentations referencing similar topics