Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier

  title={Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier},
  author={William A. Banks and Abba J. Kastin},
  journal={Neuroscience \& Biobehavioral Reviews},
Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells
Assessment of the modulation of Al on purinergic system parameters of microglial cells provides new insights into the involvement of the purinerential system in the mechanisms underlying Al toxicity in microglia cells.
Mercury neurotoxicity: Mechanisms of blood-brain barrier transport
The Pharmacokinetics and Toxicology of Aluminum in the Brain
Although a non-essential metal, there are mechanisms enabling aluminum to get into the brain, accumulating over the lifespan, and creating the potential to contribute to many neurodegenera- tive disorders.
Neurotoxicology of the Brain Barrier System: New Implications
  • Wei Zheng
  • Chemistry, Biology
    Journal of toxicology. Clinical toxicology
  • 2001
This review examines what is currently understood about brain barrier systems in central nervous system disorders by focusing on chemical-induced neurotoxicities including those associated with nitrobenzenes, N-methyl-D-aspartate, cyclosporin A, pyridostigmine bromide, aluminum, lead, manganese and 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Entry and Deposit of Aluminum in the Brain.
  • Lin-ping Wang
  • Biology
    Advances in experimental medicine and biology
  • 2018
Aluminum, as a known neurotoxicant, contributes to cognitive dysfunction and may contribute to Alzheimer's disease, and some factors, such as the increasing of the blood-brain barrier permeability, citric acid and parathyroid hormone, and vitamin D, can promote aluminum to enter the brain.


Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.
It is found that aluminum rapidly and profoundly inhibited the saturable system that transports the small, N-tyrosinated peptides Tyr-MIF-1 and the enkephalins from the brain to the blood by acting as a noncompetitive inhibitor.
Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids.
  • W. Banks, A. Kastin
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1986
There is evidence that the carrier-mediated system capable of transporting small, N-tyrosinated peptides across the blood-brain barrier is modulated by intraventricularly administered leucine, raising the possibility that the toxicity of amino acids on the central nervous system may be mediated in part by alterations in blood- brain barrier function.
Cationic atmosphere and cation competition binding at negatively charged membranes: pathological implications of aluminum.
  • M. Deleers
  • Chemistry, Biology
    Research communications in chemical pathology and pharmacology
  • 1985
The binding ofAl3+ and the displacement of Ca2+ by Al3+ is studied with the aid of a simple mathematical approach described here and giving the same results when compared to the mathematical formalism described by Nir and Bentz.