Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier

@article{Banks1989AluminumInducedNA,
  title={Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier},
  author={William A. Banks and Abba J. Kastin},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1989},
  volume={13},
  pages={47-53}
}
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References

SHOWING 1-10 OF 85 REFERENCES
Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.
TLDR
It is found that aluminum rapidly and profoundly inhibited the saturable system that transports the small, N-tyrosinated peptides Tyr-MIF-1 and the enkephalins from the brain to the blood by acting as a noncompetitive inhibitor.
Aluminum alters the permeability of the blood-brain barrier to some non-peptides
Aluminum induced reversible change in permeability of the blood-brain barrier to [14C]sucrose
Permeability of the blood-brain barrier to neuropeptides: The case for penetration
ALUMINIUM INCREASES PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO LABELLED DSIP AND β-ENDORPHIN: POSSIBLE IMPLICATIONS FOR SENILE AND DIALYSIS DEMENTIA
Aluminum effects on brain microvessel endothelial cell monolayer permeability
Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability
Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids.
  • W. Banks, A. Kastin
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1986
TLDR
There is evidence that the carrier-mediated system capable of transporting small, N-tyrosinated peptides across the blood-brain barrier is modulated by intraventricularly administered leucine, raising the possibility that the toxicity of amino acids on the central nervous system may be mediated in part by alterations in blood- brain barrier function.
Cationic atmosphere and cation competition binding at negatively charged membranes: pathological implications of aluminum.
  • M. Deleers
  • Chemistry, Biology
    Research communications in chemical pathology and pharmacology
  • 1985
TLDR
The binding ofAl3+ and the displacement of Ca2+ by Al3+ is studied with the aid of a simple mathematical approach described here and giving the same results when compared to the mathematical formalism described by Nir and Bentz.
Effects of metal ions and chelating agents on in vitro stability of glucocorticoid receptors in brain cytosol.
...
...