Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier

  title={Aluminum-Induced neurotoxicity: Alterations in membrane function at the blood-brain barrier},
  author={W. Banks and A. Kastin},
  journal={Neuroscience & Biobehavioral Reviews},
  • W. Banks, A. Kastin
  • Published 1989
  • Chemistry, Medicine
  • Neuroscience & Biobehavioral Reviews
  • Aluminum is established as a neurotoxin, although the basis for its toxicity is unknown. It recently has been shown to alter the function of the blood-brain barrier (BBB), which regulates exchanges between the central nervous system (CNS) and peripheral circulation. The BBB owes its unique properties to the integrity of the cell membranes that comprise it. Aluminum affects some of the membrane-like functions of the BBB. It increases the rate of transmembrane diffusion and selectively changes… CONTINUE READING
    165 Citations

    Paper Mentions

    Manganese neurotoxicity: Cellular effects and blood-brain barrier transport
    • 253
    Mercury neurotoxicity: Mechanisms of blood-brain barrier transport
    • 303
    The Pharmacokinetics and Toxicology of Aluminum in the Brain
    • 13
    • PDF
    Neurotoxicology of the Brain Barrier System: New Implications
    • W. Zheng
    • Medicine
    • Journal of toxicology. Clinical toxicology
    • 2001
    • 88
    • PDF
    Entry and Deposit of Aluminum in the Brain.
    • L. Wang
    • Chemistry, Medicine
    • Advances in experimental medicine and biology
    • 2018
    • 4


    Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.
    • 66
    Aluminum alters the permeability of the blood-brain barrier to some non-peptides
    • 60
    Permeability of the blood-brain barrier to neuropeptides: The case for penetration
    • 123
    Peptides and the blood-brain barrier: Lipophilicity as a predictor of permeability
    • 276
    Modulation of the carrier-mediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids.
    • W. Banks, A. Kastin
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1986
    • 37
    Cationic atmosphere and cation competition binding at negatively charged membranes: pathological implications of aluminum.
    • M. Deleers
    • Chemistry, Medicine
    • Research communications in chemical pathology and pharmacology
    • 1985
    • 57