Aluminium toxicity and metal speciation: established data and open questions

@article{Corain1996AluminiumTA,
  title={Aluminium toxicity and metal speciation: established data and open questions},
  author={B. Corain and G. Bombi and A. Tapparo and M. Perazzolo and P. Zatta},
  journal={Coordination Chemistry Reviews},
  year={1996},
  volume={149},
  pages={11-22}
}
Histopathological findings in humans and extensive toxicological investigation in vivo and in vitro point to an unambiguous neurotoxic potency of AI(III). Experimental toxicology with aqueous AI(III) is very difficult owing to the complex and somewhat uncontrollable aqueous chemistry of the metal centre in the neutral range. The choice of neutral, hydrolytically stable synthetic toxins makes possible both the control of metal speciation and of analytical metal concentration down to about 1 mM… Expand
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Aluminium(III) solutions suitable for careful toxicological investigation both in vivo and in vitro, are prepared from AlCl3·6H2O and from neutral metal complexes, Al(lactate)3, Al2(citrate)2(H2O)6,Expand
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Al3+ is expected to complex with oxygen donor ligands, especially phosphates, and it does so in soils, in the gastrointestinal tract, and in cells, and an appreciable fraction occurs as a neutral complex that may pass through membranes and provide a vehicle for Al3+ absorption into the body. Expand
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