Alum's adjuvant action: grease is the word

  title={Alum's adjuvant action: grease is the word},
  author={M. Lamine Mbow and Ennio de Gregorio and Jeffrey B. Ulmer},
  journal={Nature Medicine},
Alum is the most widely used vaccine adjuvant, but its mechanism of action remains largely unknown. A recent study shows that alum interacts directly with membrane lipids on the surface of dendritic cells, triggering signaling cascades that promote CD4+ T cell activation and humoral immune responses (pages 479–487). 
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  • Scientific Reports
  • 2020
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Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
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Towards an understanding of the adjuvant action of aluminium
The initial discovery of aluminium adjuvants was first discovered empirically in 1926 and their implications and the remaining questions on how these adjuvant work are discussed. Expand
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Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
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Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro.
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The frequency of peritonitis is remarkable, as it accounts for almost half the deaths; where the responsible organism has been found to be pneumococcus, one should bear in miind that two baciteri,al toxins aire definiitely kniown to select the g;lomeuuIlltls of the kidniey for attack. Expand