Alu element mutation spectra: molecular clocks and the effect of DNA methylation.

@article{Xing2004AluEM,
  title={Alu element mutation spectra: molecular clocks and the effect of DNA methylation.},
  author={Jinchuan Xing and Dale J. Hedges and Kyudong Han and Hui Wang and Richard Cordaux and Mark A Batzer},
  journal={Journal of molecular biology},
  year={2004},
  volume={344 3},
  pages={
          675-82
        }
}
In primate genomes more than 40% of CpG islands are found within repetitive elements. With more than one million copies in the human genome, the Alu family of retrotransposons represents the most successful short interspersed element (SINE) in primates and CpG dinucleotides make up about 20% of Alu sequences. It is generally thought that CpG dinucleotides mutate approximately ten times faster than other dinucleotides due to cytosine methylation and the subsequent deamination and conversion of C… CONTINUE READING
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