Alu-SINE exonization: en route to protein-coding function.

@article{Krull2005AluSINEEE,
  title={Alu-SINE exonization: en route to protein-coding function.},
  author={Maren Krull and J{\"u}rgen Brosius and J{\"u}rgen Schmitz},
  journal={Molecular biology and evolution},
  year={2005},
  volume={22 8},
  pages={
          1702-11
        }
}
The majority of more than one million primate-specific Alu elements map to nonfunctional parts of introns or intergenic sequences. Once integrated, they have the potential to become exapted as functional modules, e.g., as protein-coding domains via alternative splicing. This particular process is also termed exonization and increases protein versatility. Here we investigate 153 human chromosomal loci where Alu elements were conceivably exonized. In four selected examples, we generated, with the… CONTINUE READING

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