Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery

@article{Schwartz2009AluEE,
  title={Alu Exonization Events Reveal Features Required for Precise Recognition of Exons by the Splicing Machinery},
  author={Schraga Schwartz and Nurit Gal-Mark and Nir Kfir and Ram Oren and Eddo Kim and Gil Ast},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={291 - 336}
}
Despite decades of research, the question of how the mRNA splicing machinery precisely identifies short exonic islands within the vast intronic oceans remains to a large extent obscure. In this study, we analyzed Alu exonization events, aiming to understand the requirements for correct selection of exons. Comparison of exonizing Alus to their non-exonizing… CONTINUE READING