Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.

@article{Madras1998AltropaneAS,
  title={Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.},
  author={Bertha K. Madras and L M Gracz and Michele A Fahey and David R. Elmaleh and Peter C. Meltzer and Anna Y. Liang and Edward G. Stopa and John W Babich and Alan J. Fischman},
  journal={Synapse},
  year={1998},
  volume={29 2},
  pages={116-27}
}
Increasing evidence suggests that the dopamine transporter is situated almost exclusively on dopamine neurons. Accordingly, it is an valuable marker for Parkinson's disease and other pathological states of dopamine neurons. We previously demonstrated that the potent dopamine transport inhibitor [125I]altropane (IACFT:E-N-iodoallyl-2beta-carbomethoxy-3beta-(4-fluor ophenyl)tropane) is a high affinity selective probe for the dopamine transporter in monkey brain and an effective SPECT imaging… CONTINUE READING