Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass.

@article{Segesser2001AlternativesTU,
  title={Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass.},
  author={Ludwig K. von Segesser and Xavier M. Mueller and Bruno Marty and Judith Horisberger and Antonio Corno},
  journal={Perfusion},
  year={2001},
  volume={16 5},
  pages={
          411-6
        }
}
Despite the progress made in the development of cardiopulmonary bypass (CPB) equipment, systemic anticoagulation with unfractionated heparin and post-bypass neutralization with protamine are still used in most perfusion procedures. However, there are a number of situations where unfractionated heparin, protamine or both cannot be used for various reasons. Intolerance of protamine can be addressed with extracorporeal heparin removal devices, perfusion with (no) low systemic heparinization and… CONTINUE READING