Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption.

@article{Scholz2013AlternativesTI,
  title={Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption.},
  author={Stefan Scholz and Patrick Renner and Scott E Belanger and François Busquet and Ruthanna C Davi and Barbara A Demeneix and Jeffrey S Denny and Marissa Leonard and Mark E. McMaster and Dan L Villeneuve and M R Embry},
  journal={Critical reviews in toxicology},
  year={2013},
  volume={43 1},
  pages={45-72}
}
Endocrine disruption is considered a highly relevant hazard for environmental risk assessment of chemicals, plant protection products, biocides and pharmaceuticals. Therefore, screening tests with a focus on interference with estrogen, androgen, and thyroid hormone pathways in fish and amphibians have been developed. However, they use a large number of animals and short-term alternatives to animal tests would be advantageous. Therefore, the status of alternative assays for endocrine disruption… CONTINUE READING
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