Alternatives to Sodium Amobarbital in the Wada Test

@article{Patel2011AlternativesTS,
  title={Alternatives to Sodium Amobarbital in the Wada Test},
  author={Akta Patel and Cindy J. Wordell and Dorata Szarlej},
  journal={Annals of Pharmacotherapy},
  year={2011},
  volume={45},
  pages={395 - 401}
}
Objective: To review the literature and identify alternatives to sodium amobarbital for use in the Wada test. Data Sources: A search of PubMed (1960-October 2010) was performed using the following key words alone or in combination: Wada test, intracarotid amobarbital procedure, intracarotid, intraarterial, sodium amobarbital, methohexital, Brevital, pentobarbital, etomidate, propofol, and alternative anesthetics. References of the identified articles were reviewed for relevant information… 

Tables from this paper

Intracarotid Etomidate is a Safe Alternative to Sodium Amobarbital for the Wada Test
TLDR
Etomidate is a safe alternative to sodium amobarbital for the Wada test for determining the hemispheric dominance for speech and in predicting the memory outcome.
The Optimal Dose of Amobarbital in the Wada Test for the Presurgical Evaluation of Patients With Temporal Lobe Epilepsy
TLDR
It was only the patient's age that could influence the modification of Amobarbital dose in the Wada test, yet establishing a universal protocol is challenging because of the lack of well-defined dose determinants.
Dexmedetomidine Sedation for WADA Test With Intracarotid Propofol in Pediatric Patients.
TLDR
Two cases of successful use of dexmedetomidine sedation in pediatric patients (6-y-old male and 7-yold female) during selective middle cerebral artery WADA test with intracarotid propofol are reported.
Propofol as a substitute for amobarbital in Wada testing
Bilateral Wada test: Amobarbital or propofol?
Tolerability of propofol in Wada testing
TLDR
It is found that propofol is well tolerable for the Wada test, with minimally significant complications, although blood pressure should be closely monitored.
Influence of Strapping of the Hand on Non- invasive Hemoglobin Measurements
TLDR
This work has shown that dexmedetomidine sedation on the EEG in children with a history of seizure disorders and sedative and hypnotic doses of propofol have a similar effect on the activity of the brain waves of patients with or without a historyof seizure disorders.
Influence of Strapping of the Hand on Noninvasive Hemoglobin Measurements.
TLDR
This work has shown that dexmedetomidine sedation on the EEG in children with a history of seizure disorders and sedative and hypnotic doses of propofol have a similar effect on the activity of the brain waves of patients with or without a historyof seizure disorders.
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References

SHOWING 1-10 OF 41 REFERENCES
Etomidate speech and memory test (eSAM)
TLDR
Etomidate is a viable alternative to amobarbital, and its administration by bolus followed by infusion offers an improvement over the traditional intracarotid amobarBital procedure.
Can pentobarbital replace amobarbital in the Wada test?
Intracarotid propofol test for speech and memory dominance in man
TLDR
With direct intracarotid propofol injection, the Wada test was satisfactorily performed in all 12 patients and 2 more patients with left-handedness or with different injection dose for each side without any complications.
Wada testing in pediatric patients by use of propofol anesthesia.
TLDR
Propofol provided rapid induction of anesthesia, was administered without endotracheal intubation, and did not cause substantial changes in cardiorespiratory parameters.
Has amobarbital expired?
TLDR
The intracarotid amobarbital procedure has emerged in epilepsy surgery centers around the world as the standard method to lateralize speech and memory functions and to prevent or predict the magnitude of related declines following epilepsy surgery.
Intracarotid amobarbital procedure and etomidate speech and memory test.
TLDR
The Montreal Neurological Institute experience using etomidate in place of amobarbital and introducing a significant change in the procedure: after an initial bolus injection, an infusion is used to maintain the level of hemianesthesia during critical test times.
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