Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.

@article{Hrdlikov2012AlternativelyST,
  title={Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation.},
  author={Radmila Hrdli{\vc}kov{\'a} and Jiř{\'i} Nehyba and Henry R. Bose},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 21},
  pages={4283-96}
}
Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in-frame deletion which removed exons 4 through 13, encoding the catalytic domain of telomerase. This variant was expressed in telomerase-negative normal cells and tissues as well as in transformed telomerase-positive cell lines and cells which employ an alternative method to maintain telomere length. The overexpression… CONTINUE READING