Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.

@article{Pterfy2005AlternativelySL,
  title={Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.},
  author={Mikl{\'o}s P{\'e}terfy and Jack Phan and Karen Reue},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 38},
  pages={
          32883-9
        }
}
We recently identified mutations in the Lpin1 (lipin) gene to be responsible for lipodystrophy in the fatty liver dystrophy (fld) mouse strain. Previous studies revealed that lipin plays a critical role in adipogenesis, explaining the adipose-deficient phenotype of the fld mouse. In the current study, we demonstrate that alternative mRNA splicing generates two lipin isoforms, lipin-alpha and lipin-beta, which are differentially expressed during adipocyte differentiation. Lipin-alpha expression… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 104 CITATIONS

Lipin proteins and glycerolipid metabolism: Roles at the ER membrane and beyond.

  • Biochimica et biophysica acta. Biomembranes
  • 2017
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling.

  • Progress in lipid research
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

  • Genes & development
  • 2008
VIEW 7 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis.

VIEW 7 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Subcellular localization and role of lipin-1 in human macrophages.

  • Journal of immunology
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 13 Highly Influenced Citations

  • Averaged 5 Citations per year over the last 3 years

Similar Papers

Loading similar papers…