Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein

  title={Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein},
  author={V. Bogdanov and V. Balasubramanian and J. Hathcock and Oana Vele and M. Lieb and Y. Nemerson},
  journal={Nature Medicine},
  • V. Bogdanov, V. Balasubramanian, +3 authors Y. Nemerson
  • Published 2003
  • Biology, Medicine
  • Nature Medicine
  • Tissue factor (TF) is an essential enzyme activator that forms a catalytic complex with FVIIa and initiates coagulation by activating FIX and FX, ultimately resulting in thrombin formation. TF is found in adventitia of blood vessels and the lipid core of atherosclerotic plaques. In unstable coronary syndromes, plaque rupture initiates coagulation by exposing TF to blood. Biologically active TF has been detected in vessel walls and circulating blood. Elevated intravascular TF has been reported… CONTINUE READING
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