Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling.

@article{Kalea2010AlternativelySR,
  title={Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling.},
  author={Anastasia Z. Kalea and Fiona See and Evis Harja and Mar{\'i}a del Mar Arriero and Ann Marie Schmidt and Barry I. Hudson},
  journal={Cancer research},
  year={2010},
  volume={70 13},
  pages={5628-38}
}
Receptor for advanced glycation end products (RAGE) and its ligands are overexpressed in multiple cancers. RAGE has been implicated in tumorigenesis and metastasis, but little is known of the mechanisms involved. In this study, we define a specific functional role for an alternate splice variant termed RAGE splice variant 1 (RAGEv1), which encodes a soluble endogenous form of the receptor that inhibits tumorigenesis. RAGEv1 was downregulated in lung, prostate, and brain tumors relative to… CONTINUE READING

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