Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice.

@article{Derecki2011AlternativelyAM,
  title={Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice.},
  author={Noel Christopher Derecki and Kayla M. Quinnies and Jonathan Kipnis},
  journal={Brain, behavior, and immunity},
  year={2011},
  volume={25 3},
  pages={379-85}
}
It was recently shown that adaptive immunity plays a key role in cognitive function. T cells appear to be major players in learning and memory; thus, mice devoid of functional T cells are impaired in performance of cognitive tasks such as Morris water maze (MWM), Barnes maze and others. This is a reversible phenomenon; injection of immune deficient mice with T cells from wild type counterparts improves their cognitive function. Recently we described a critical role for T cell-derived IL-4 as… CONTINUE READING

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