Alternatively activated macrophages in helminth infections.

  title={Alternatively activated macrophages in helminth infections.},
  author={Timothy R Kreider and Robert M. Anthony and Joseph J. Urban and William C. Gause},
  journal={Current opinion in immunology},
  volume={19 4},
Helminthic parasites can trigger highly polarized immune responses typically associated with increased numbers of CD4(+) Th2 cells, eosinophils, mast cells, and basophils. These cell populations are thought to coordinate an effective response ultimately leading to parasite expulsion, but they also play a role in the regulation of associated pathologic inflammation. Recent studies suggest that macrophages, conventionally associated with IFN-gamma-dominant Th1-type responses to many bacteria and… CONTINUE READING
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