Alternative view of enzyme reactions.

@article{Dewar1985AlternativeVO,
  title={Alternative view of enzyme reactions.},
  author={Michael J. S. Dewar and D M Storch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 8},
  pages={2225-9}
}
Since adsorption of the substrate in the active site of an enzyme can occur only if all solvent is squeezed out from between them, any reaction between them takes place in the absence of any intervening solvent--i.e., as it would in the gas phase. Recent work has shown that ionic reactions in the gas phase often differ greatly from analogous processes in solution. Therefore, current interpretations of enzyme reactions in terms of solution chemistry are misguided. The large rates and specificity… CONTINUE READING

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