Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.

@article{Dme2007AlternativeVM,
  title={Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications.},
  author={Bal{\'a}zs D{\"o}me and Mary J. C. Hendrix and S{\'a}ndor Paku and J{\'o}zsef T{\'o}v{\'a}ri and J{\'o}zsef T{\'i}m{\'a}r},
  journal={The American journal of pathology},
  year={2007},
  volume={170 1},
  pages={1-15}
}
Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor growth is highly dependent on the supply of oxygen, nutrients, and host-derived regulators. It is now established that tumor vasculature is not necessarily derived from endothelial cell sprouting; instead, cancer tissue can acquire its vasculature by co-option of pre-existing vessels, intussusceptive microvascular growth, postnatal vasculogenesis, glomeruloid angiogenesis, or vasculogenic mimicry. The best… CONTINUE READING