Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities.

@article{Fukushima2012AlternativeTI,
  title={Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities.},
  author={Miwako Fukushima and Takuro Tomita and Agnes Janoshazi and James W Putney},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 18},
  pages={4354-61}
}
Store-operated calcium entry is an almost ubiquitous signaling pathway in eukaryotic cells. The plasma membrane store-operated channels are comprised of subunits of the recently discovered Orai proteins, the major one being Orai1.We have discovered that native Orai1, as well as expressed Orai1, exists in two forms in similar quantities: a longer form (Orai1α) of approximately 33 kDa, and a shorter form (Orai1β) of approximately 23 kDa. The Orai1β form arises from alternative translation… CONTINUE READING

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