Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development.

@article{Pal2011AlternativeTE,
  title={Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development.},
  author={Sharmistha Pal and Ravi Gupta and Hyunsoo Kim and Priyankara Wickramasinghe and Val{\'e}rie Baubet and Louise C. Showe and Nadia Dahmane and Ramana V. Davuluri},
  journal={Genome research},
  year={2011},
  volume={21 8},
  pages={1260-72}
}
Despite our growing knowledge that many mammalian genes generate multiple transcript variants that may encode functionally distinct protein isoforms, the transcriptomes of various tissues and their developmental stages are poorly defined. Identifying the transcriptome and its regulation in a cell/tissue is the key to deciphering the cell/tissue-specific functions of a gene. We built a genome-wide inventory of noncoding and protein-coding transcripts (transcriptomes), their promoters… CONTINUE READING
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