Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons.

@article{Prinz2003AlternativeTH,
  title={Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons.},
  author={Astrid A. Prinz and Cyrus P. Billimoria and Eve Marder},
  journal={Journal of neurophysiology},
  year={2003},
  volume={90 6},
  pages={
          3998-4015
        }
}
Conventionally, the parameters of neuronal models are hand-tuned using trial-and-error searches to produce a desired behavior. Here, we present an alternative approach. We have generated a database of about 1.7 million single-compartment model neurons by independently varying 8 maximal membrane conductances based on measurements from lobster stomatogastric neurons. We classified the spontaneous electrical activity of each model neuron and its responsiveness to inputs during runtime with an… Expand
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