Alternative to ganglionic blockade with anticholinergic and alpha-2 receptor agents

@article{Wilkins2006AlternativeTG,
  title={Alternative to ganglionic blockade with anticholinergic and alpha-2 receptor agents},
  author={Brad W. Wilkins and Christiane Hesse and Hans P Sviggum and Wayne T. Nicholson and Thomas P. Moyer and Michael J. Joyner and John H. Eisenach},
  journal={Clinical Autonomic Research},
  year={2006},
  volume={17},
  pages={77-84}
}
The ganglionic blocking agent trimethaphan (TMP) is no longer produced. [...] Key Method Ten volunteers participated in two study days and were instrumented with pulse oximeter, nasal cannula, ECG, continuous blood pressure monitoring (Finapres), and I.V. catheter for drug infusions. Each study day consisted of a control condition followed by either combined Gly–Dex or TMP on alternating days.Expand
Autonomic Cardiovascular Control During a Novel Pharmacologic Alternative to Ganglionic Blockade
TLDR
It is concluded that the GLY–DEX alternative drug strategy can be used as a reasonable alternative to pharmacologic ganglionic blockade to examine autonomic cardiovascular control. Expand
Alpha2-adrenoceptor-independent inhibition of acetylcholine receptor channel and sodium channel by dexmedetomidine in rat superior cervical ganglion neurons
TLDR
DMED dose-dependently inhibits INa and IACh in rat SCG neurons by preferential binding to the inactivated state of the Na(+) channels and the closed state (resting) of nAChR channels respectively. Expand
Aging Alters the Relative Contributions of the Sympathetic and Parasympathetic Nervous System to Blood Pressure Control in Women
TLDR
Loss of parasympathetic tone and increased sympathetic tone with aging contribute to the increase in blood pressure with age in women and dictate the dose of TMP that is necessary to achieve ganglionic blockade. Expand
The Valsalva maneuver: screening for drug-induced baroreflex dysfunction
TLDR
The Valsalva maneuver recapitulated complex alterations in baroreflex regulation during NET inhibition so that this simple and inexpensive test could be employed as a screening tool for drug-induced barore Flex dysfunction. Expand
An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.
TLDR
Treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate not only resulting in resolution of brady Cardia but also resulting in an exaggerated increase of arterial blood pressure is reported on. Expand
Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction
TLDR
In the 7 out of 13 patients with HFpEF with age-appropriate β–receptor sensitivity, peak HR remained low, suggesting impaired sinus node β-receptor function may not fully account for low exercise HR response. Expand
GENETIC VARIATION IN THE β(2)-ADRENERGIC RECEPTOR: IMPACT ON INTERMEDIATE CARDIOVASCULAR PHENOTYPES.
Genetic variation in drug targets (e.g. receptors) can have pronounced effects on clinical responses to endogenous and exogenous agonists. Polymorphisms in the gene encoding the β(2)-adrenergicExpand
Pharmacological probes to measure the importance of the autonomic nervous system
The primary function of the autonomic nervous system is to detect changes in the internal milieu and external environment, integrate all this information in central nervous system (CNS) centers thatExpand
Aging Enhances Autonomic Support of Blood Pressure in Women
TLDR
The results suggest that autonomic support of blood pressure is greater in Older women compared with young women and that elevated sympathetic nerve activity in older women contributes importantly to the increased incidence of hypertension after menopause. Expand
Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women.
TLDR
The results suggest that some aortic hemodynamic parameters are influenced by sympathetic activity to a greater extent in older post menopausal women than in young premenopausal women. Expand
...
1
2
...

References

SHOWING 1-10 OF 34 REFERENCES
Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm.
TLDR
The results suggest that Dex causes more alpha(2)-selective vasoconstriction in the forearm than clonidine, and the similar vasconstrictor responses to both drugs after prazosin might be explained by the presynaptic effects on norepinephrine release. Expand
The analgesic action of dexmedetomidine — a novel α 2-adrenoceptor agonist — in healthy volunteers
TLDR
FEN and DEX both had analgesic effects on ischemic pain, which was seen as a statistically significant decrease in subjective VAS ratings, and FEN appeared to be more effective than DEX; the difference was not, however, statistically significant. Expand
The analgesic action of dexmedetomidine--a novel alpha 2-adrenoceptor agonist--in healthy volunteers.
TLDR
FEN and DEX both had analgesic effects on ischemic pain, which was seen as a statistically significant decrease in subjective VAS ratings, and both appeared to be more effective than DEX; the difference was not, however, statistically significant. Expand
A comparison of dexmedetomidine, and alpha 2-adrenoceptor agonist, and midazolam as i.m. premedication for minor gynaecological surgery.
TLDR
Both premedicants decreased the plasma concentrations of noradrenaline by about 50%, but only dexmedetomidine attenuated the catecholamine response to anaesthesia and surgery. Expand
Trimethaphan is a Direct Arterial Vasodilator and an $aL‐Adrenoceptor Antagonist
TLDR
It is concluded that, unlike hexamethonium, trimethaphan acts directly on vascular smooth muscle to induce vasodilation, more prominently in extracerebral arteries than in cerebral arteries. Expand
Uncoupling of the baroreflex by N(N)-cholinergic blockade in dissecting the components of cardiovascular regulation.
TLDR
Un Uncoupling of the baroreflex by N(N)-cholinergic blockade may be a useful method to obtain an integrated measure of adrenergic receptor sensitivity and sensitivity to nitric oxide donors in humans. Expand
N(N)-nicotinic blockade as an acute human model of autonomic failure.
TLDR
It is concluded that blockade of N(N)-cholinergic receptors is useful to simulate the hemodynamic alterations of acute autonomic failure in humans and may be applied to study human cardiovascular physiology and pharmacology in the absence of confounding baroreflexes. Expand
The Effects of Increasing Plasma Concentrations of Dexmedetomidine in Humans
Background This study determined the responses to increasing plasma concentrations of dexmedetomidine in humans. Methods Ten healthy men (20–27 yr) provided informed consent and were monitoredExpand
Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine
TLDR
The pharmacokinetics and pharmacodynamics of transdermal (TD) and intravenous (IV) dexmedetomidine were studied in nine healthy male subjects in a crossover trial and a sedative effect was obvious within 5 min and 1–2 h after IV and TD administration, respectively. Expand
Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men.
TLDR
It is indicated that vasoconstricting post-junctional alpha(1)- and alpha(2)-adrenoceptors contribute more to basal vascular tone than alpha( 1-adrenOceptors in the forearms of young healthy men. Expand
...
1
2
3
4
...