Alternative therapy of Alzheimer’s disease via supplementation with choline acetyltransferase

  title={Alternative therapy of Alzheimer’s disease via supplementation with choline acetyltransferase},
  author={Ai Ling Fu and Qian Li and Zhao Hui Dong and Shi Jie Huang and Yu Xia Wang and Man-ji Sun},
  journal={Neuroscience Letters},

Choline Supplementation Ameliorates Behavioural Deficits and Alzheimer's Disease-Like Pathology in Transgenic APP/PS1 Mice.

Findings reveal a beneficial effect of CS on AD progression during adulthood and provide a likely therapeutic intervention for AD patients.

Plasma alterations in cholinergic and serotonergic systems in early Alzheimer Disease: diagnosis utility.

Alzheimer's disease Animal Model by Aluminum, Beta-Amyloid and Transforming Growth Factor Beta-1

The results showed that the cognitive ability of the model rats was damaged, neurons became derangement and karyopyknosis, moreover, senile plaques and neurofibrillary tangles were found in the cortex and hippocampus over 3 months, choline acetyl transferase was decreased, and Aβ was increased.

Prevention of age-related memory deficit in transgenic mice by human choline acetyltransferase.

Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice

The differential impact of SAM on ApoE+/+ and −/− neurons underscores the combined impact of nutritional and genetic deficiencies on neuronal homeostasis and supports the importance of dietary supplementation with folate and SAM on neuronal health.

Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis

This study evaluated the effects of H102 on expression of P-tau, several associated proteins, inflammatory factors and apoptosis factors, and examined the cognitive ability of APP transgenic mice by behavioral test.

Main Plant Extracts’ Active Properties Effective on Scopolamine-Induced Memory Loss

Many active compounds constituting the recently tested plant extracts may exhibit the same general effect on acetylcholine pathway, but on different molecular ground, which can be successfully used in Alzheimer’s disease adjuvant therapy.

Choline intervention in children with fetal alcohol spectrum disorders

The findings of the present study do not support that choline, administered at a dose of 625 mg/day for 6 weeks, is an effective intervention for children with FASD, and highlights the need for a continued understanding of the role of nutritional status and supplementation in FasD and its contributions to neurocognition.



Complementary and Alternative Medicines in the Treatment of Dementia

While a number of complementary interventions have shown both strengths and weaknesses, huperzine A, levacecarnine and EGB 761, based on the overall quality of the studies, identified mechanisms of activity and safety profiles merit further examination in controlled clinical outcome studies.

Spectrophotometric assay for choline acetyltransferase.