Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1.

@article{Francesconi2002AlternativeSU,
  title={Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1.},
  author={Anna Francesconi and Robert M. Duvoisin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 6},
  pages={2196-205}
}
Precise targeting of neurotransmitter receptors to different neuronal compartments is a fundamental step for the establishment and function of synaptic circuitry. Group I metabotropic glutamate receptors, mGluR1 and mGluR5, control glutamatergic neurotransmission by acting both postsynaptically and presynaptically. Four alternatively spliced variants of the mGluR1 gene exist, which differ in their signaling properties and subcellular localization. The present study was undertaken to identify… CONTINUE READING

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