Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions

@inproceedings{Mauger2015AlternativeSR,
  title={Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions},
  author={Oriane Mauger and Roscoe Klinck and Benoit Chabot and Christian Muchardt and Eric Allemand and Eric Batsch{\'e}},
  booktitle={Nucleic acids research},
  year={2015}
}
Alternative splicing is the main source of proteome diversity. Here, we have investigated how alternative splicing affects the function of two human histone methyltransferases (HMTase): G9A and SUV39H2. We show that exon 10 in G9A and exon 3 in SUV39H2 are alternatively included in a variety of tissues and cell lines, as well as in a different species. The production of these variants is likely tightly regulated because both constitutive and alternative splicing factors control their splicing… CONTINUE READING

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