Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency.

@article{Gu2012AlternativeSR,
  title={Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency.},
  author={Yuanzheng Gu and Joshua Barry and Robert McDougel and David Terman and Chen Gu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 3},
  pages={1755-69}
}
Synaptic inputs received at dendrites are converted into digital outputs encoded by action potentials generated at the axon initial segment in most neurons. Here, we report that alternative splicing regulates polarized targeting of Kv3.1 voltage-gated potassium (Kv) channels to adjust the input-output relationship. The spiking frequency of cultured hippocampal neurons correlated with the level of endogenous Kv3 channels. Expression of axonal Kv3.1b, the longer form of Kv3.1 splice variants… CONTINUE READING

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