Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

@article{Strathmann1990AlternativeSP,
  title={Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.},
  author={M P Strathmann and Thomas M. Wilkie and Melvin I. Simon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 17},
  pages={6477-81}
}
The alpha subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go alpha subunit were isolated from a mouse brain library. These two forms, which we call GoA alpha and GoB alpha, appear to be the products of alternative splicing. GoA alpha differs from GoB alpha over the C-terminal third of the deduced protein sequence. Both forms are predicted to be… CONTINUE READING