Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.

@article{Najafi2017AlternativeSO,
  title={Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway.},
  author={Hadi Najafi and Bahram Mohammad Soltani and Sadat Dokanehiifard and Shirzad Nasiri and Seyed Javad Mowla},
  journal={RNA},
  year={2017},
  volume={23 1},
  pages={70-85}
}
The Wnt signaling pathway is hyperactivated in most colorectal cancers (CRC). Finding new regulators of this pathway represents the potential for cancer diagnosis or treatment. OCC-1 was initially reported as an up-regulated gene in colon carcinoma, without knowing its mechanism of action. Here, two novel transcript variants and an exonic microRNA that originated from the OCC-1 gene are reported, showing positive effects on Wnt activity. Up-regulation of the known OCC-1 variant (assigned as OCC… CONTINUE READING
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