Alternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis.

@article{Mnch2002AlternativeSO,
  title={Alternative splicing of the 5'-sequences of the mouse EAAT2 glutamate transporter and expression in a transgenic model for amyotrophic lateral sclerosis.},
  author={Christoph M{\"u}nch and M Ebstein and Ulrich Seefried and Bing-gen Zhu and Stefan Stamm and Georg Bernhard Landwehrmeyer and Albert Christian Ludolph and Birgit Schwalenst{\"o}cker and Thomas Meyer},
  journal={Journal of neurochemistry},
  year={2002},
  volume={82 3},
  pages={594-603}
}
Glutamate-mediated neurotoxicity and a reduced expression of the excitatory amino acid transporter 2 (EAAT2) have been described in the pathogenesis of several acute and chronic neurological conditions. EAAT2 is the major carrier of glutamate in the mammalian brain. However, the principles of EAAT2 expression regulation are not fully understood. For the human brain, extensive alternative splicing of the EAAT2 RNA has been shown. To delineate the complex RNA regulation of EAAT2 we investigated… CONTINUE READING