Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis.

@article{George2007AlternativeSO,
  title={Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis.},
  author={Christopher H George and Sarah A. Rogers and Benedicte M. A. Bertrand and Richard E A Tunwell and Nathan L. Thomas and Derek Steele and Eryl V. Cox and Christopher Pepper and Carolyn J. Hazeel and William C. Claycomb and F Anthony Lai},
  journal={Circulation research},
  year={2007},
  volume={100 6},
  pages={874-83}
}
Ca(2+) release via type 2 ryanodine receptors (RyR2) regulates cardiac function. Molecular cloning of human RyR2 identified 2 alternatively spliced variants, comprising 30- and 24-bp sequence insertions; yet their role in shaping cardiomyocyte Ca(2+) signaling and cell phenotype is unknown. We profiled the developmental regulation and the tissue and species specificity of these variants and showed that their recombinant expression in HL-1 cardiomyocytes profoundly modulated nuclear and… CONTINUE READING

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