Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails.

@article{Hermey2000AlternativeSO,
  title={Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails.},
  author={Guido Hermey and H. Chica Schaller},
  journal={Biochimica et biophysica acta},
  year={2000},
  volume={1491 1-3},
  pages={350-4}
}
We report the identification of a splice variant of SorCS, a member of the family of VPS10 domain containing receptors. These type I transmembrane proteins share the presence of internalization signals in their cytoplasmic tail as one common characteristic. We show that an alternatively spliced transcript of SorCS is generated by differential processing of a composite internal/terminal exon. This splice variant encodes a protein with an N-terminal VPS10 domain followed by a leucine-rich module… CONTINUE READING