Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA.

@article{Indik1987AlternativeSO,
  title={Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA.},
  author={Zena K. Indik and H Yeh and Norma Ornstein-Goldstein and Phil Sheppard and Nix Anderson and J C Rosenbloom and L. Peltonen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 16},
  pages={
          5680-4
        }
}
Poly(A)+ RNA, isolated from a single 7-mo fetal human aorta, was used to synthesize cDNA by the RNase H method, and the cDNA was inserted into lambda gt10. Recombinant phage containing elastin sequences were identified by hybridization with cloned, exon-containing fragments of the human elastin gene. Three clones containing inserts of 3.3, 2.7, and 2.3 kilobases were selected for further analysis. Three overlapping clones containing 17.8 kilobases of the human elastin gene were also isolated… CONTINUE READING

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