Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.

@article{Rahman2002AlternativeSO,
  title={Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.},
  author={Lambratu Rahman and Valery Bliskovski and William Reinhold and Maria Zajac-Kaye},
  journal={Genomics},
  year={2002},
  volume={80 3},
  pages={245-9}
}
Splicing of neural-specific exons is differentially regulated in neuronal and non-neuronal cells. The polypyrimidine tract binding protein (PTB) has been implicated as a negative regulator for exon splicing, whereas the brain-specific homolog of PTB, termed nPTB, promotes exon splicing exclusively in neurons. We have now isolated a novel mRNA splice variant of nPTB from non-neuronal cells. In contrast to the neural nPTB transcript, the expression of this novel isoform was absent from brain… CONTINUE READING

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