Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.

@article{Rhein2017AlternativeSO,
  title={Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression.},
  author={Cosima Rhein and M Reichel and Marcel Kramer and Andrea Rotter and Bernd Lenz and Christiane M{\"u}hle and Erich Gulbins and Johannes Kornhuber},
  journal={Journal of affective disorders},
  year={2017},
  volume={209},
  pages={
          10-15
        }
}
BACKGROUND Major depressive disorder (MDD) is a psychiatric disorder characterized by key symptoms that include depressed mood and a loss of interest and pleasure. A recently developed pathogenic model of MDD involves disturbed neurogenesis in the hippocampus, where the acid sphingomyelinase (ASM)/ceramide system plays an important role and is proposed as a molecular target for antidepressant action. Because alternative splicing of SMPD1 mRNA, coding for ASM, is relevant for the regulation of… CONTINUE READING
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