Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

@article{Kozmk1993AlternativeSO,
  title={Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.},
  author={Zbyněk Kozm{\'i}k and Robert Kurzbauer and Petra Doerfler and Meinrad Busslinger},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 10},
  pages={6024-35}
}
Pax-8, a member of the paired box-containing gene family, was shown to be coexpressed with Pax-2 in several human kidney carcinoma cell lines. Four different Pax-8 mRNA isoforms, a to d, were cloned from one of these cell lines by polymerase chain reaction amplification, and the Pax-8 gene was isolated from a human cosmid library. Analysis of the exon-intron structure of Pax-8 revealed that the four mRNA isoforms arise by alternative splicing, resulting in inclusion or exclusion of exon 7 and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Similar Papers

Loading similar papers…