Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents.

@article{Pan2001AlternativeSO,
  title={Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents.},
  author={Zhi Pan and Alexander A Selyanko and Jennifer K Hadley and Deborah A. Brown and Jane E. Dixon and David McKinnon},
  journal={The Journal of physiology},
  year={2001},
  volume={531 Pt 2},
  pages={347-58}
}
The region of alternative splicing in the KCNQ2 potassium channel gene was determined by RNase protection analysis of KCNQ2 mRNA transcripts. Systematic analysis of KCNQ2 alternative splice variant expression in rat superior cervical ganglia revealed multiple variant isoforms. One class of KCNQ2 splice variants, those that contained exon 15a, was found to have significantly different kinetics to those of the other isoforms. These transcripts encoded channel subunits that, when co-expressed with… CONTINUE READING
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