Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.

@article{Ishitani1992AlternativeSO,
  title={Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens.},
  author={Akiko Ishitani and Daniel E. Geraghty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 9},
  pages={3947-51}
}
We have investigated HLA-G mRNA expression in cells and tissues expressing the gene. This analysis has demonstrated that the HLA-G primary transcript is alternatively spliced to yield at least three distinct mature mRNAs. Sequencing of the transcripts has shown that the largest mRNA is essentially that previously characterized, encoding a leader sequence, three external domains, a transmembrane region, and a cytoplasmic sequence. Of the two smaller messages, a 900-base mRNA does not include… CONTINUE READING

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