Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression.

@article{Pisarchik2001AlternativeSO,
  title={Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression.},
  author={Alexander Pisarchik and Andrzej T Slominski},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 14},
  pages={2754-6}
}
We identified four new isoforms of human CRH-R1 (e-h) and three of mouse (mCRH-R1c, e, and f). In all new forms exon 6 was missing. Human CRH-R1e was characterized by the deletion of exons 3 and 4; exon 12 from CRH-R1f; exon 11, 27 base pairs (bp) of exon 10 and 28 bp of exon 12 from CRH-R1g and CRH-R1h by the addition of a cryptic exon. In mouse CRH-R1c exon 3 was spliced out; in mCRH-R1e exons 3 and 4 and in mCRH-R1f exon 11 were spliced from mRNA. CRH-R1 was expressed in all skin specimens… CONTINUE READING