Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications

@article{Akgul2004AlternativeSO,
  title={Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications},
  author={Cahit Akgul and Dale Moulding and S W Edwards},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2189-2199}
}
Apoptosis is a morphologically distinct form of cell death. It is executed and regulated by several groups of proteins. Bcl-2 family proteins are the main regulators of the apoptotic process acting either to inhibit or promote it. More than 20 members of the family have been identified so far and most have two or more isoforms. Alternative splicing is one of the major mechanisms providing proteomic complexity and functional diversification of the Bcl-2 family proteins. Pro- and anti-apoptotic… CONTINUE READING